Pie chart of our expertise

Bespoke Study Design

Never an off the shelf solution, we construct the most appropriate study design and data source based on the needs of your project.

Collaborative RWE Experts

Our teams deliver robust studies benefiting from diverse, comprehensive knowledge spanning RWE methodologies and geographies to support our client’s global evidence generation needs.

Innovative & Pragmatic

Combining practicality with bespoke time-saving innovations to generate evidence aligned to RWE recommendations, as efficiently as possible.

Our RWE team has extensive global and regional market expertise to effectively address the logistical and scientific challenges of RWE studies

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Data Source Mapping

High quality RWE starts with identification of the right data. Our data source mapping service supports clients to identify, characterise, and critically appraise potential RWD sources.

This enables data to be selected for real-world studies in a systematic and fully informed manner.

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Infectious Disease Modelling Support

Costello Medical has more than 10 years of experience working across 40 different infectious diseases. We understand the huge impact they can have on health, at both the patient and population level.

Our specialised real-world evidence team in infectious disease modelling brings together our statistical and epidemiological expertise. This team combines our multi-disciplinary experience to deliver end-to-end support from data sourcing and expert modelling (forecasting, transmission models and treatment/vaccine validation) to clear scientific reporting.

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How can Costello Medical meet your RWE needs?

Our RWE team can support you with evidence generation for a wide range of gaps, including:

  • Disease epidemiology, treatment patterns and patient pathways
  • Healthcare resource use and disease burden
  • Patient experience and quality of life
  • Comparative effectiveness (including external control arms)

There are opportunities to leverage RWE throughout the product lifecycle

Real-World Evidence timeline

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RWE Strategic Support

Using our extensive experience in Market Access and HTA, our team help to devise a RWE generation plan that underpins your product’s value proposition. To support our client’s strategy, our RWE experts can:

  • Assess your value proposition and identify evidence gaps
  • Provide a range of evidence generation recommendations
  • Identify and access suitable data
  • Design and conduct RWE studies to complement evidence gaps
  • Communicate findings to stakeholders
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Study Design

Our RWE experts are on hand to support with all aspects of real-world study design, including:

  • Study conceptulisation and planning
  • Protocol and statistical analysis plan development
  • Study reporting and communication of findings

With our dedicated in-house Patient Engagement team, we are fully equipped to design and conduct studies to generate primary data. Our team partners with Patient Advocacy Groups to recruit study participants and ensure patient-centric research. Additionally, we can collaborate with panel recruitment vendors to recruit participants.

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Primary Data Studies

Where bespoke evidence collection is required, we have a wide range of expertise and capability in primary data studies. We work with our clients to understand their specific needs and employ the most appropriate study design to comprehensively address your research question.

We understand the complex organisational support our clients require and have extensive expertise in navigating clinical study compliance. We offer flexible services, including full or functional study management, as well as project consultancy, covering:

  • Study site identification and selection
  • Site management, incl; contracting, set-up & payment
  • Essential document development
  • Ethical and regulatory submissions & compliance
  • Data extraction, management & analysis
  • Study participant recruitment  including employing innovative methods such as decentralised approaches,  including utilising panel recruitment vendors and Patient Advisory Groups (PAGs)

Get in touch with Miranda Townsend, our Study Management Services Lead, for more information.

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Secondary Data Studies

Our team of epidemiologists and statisticians has extensive experience in analysing secondary data sources to generate valuable real-world insights for our clients. With proven expertise in electronic health records, insurance claims data, and registry datasets, we programme studies and analyse RWD to uncover previously hidden patterns, trends, and associations. This approach allows us to deliver comprehensive, evidence-based findings that support healthcare decision-making and optimise patient outcomes.

Evidence Generation Strategy

  • Data source mapping
  • RWD landscaping
  • Feasibility assessment
  • Target trial protocol
  • Evidence gap analysis / prioritisation
  • Evidence generation recommendations

Primary Data Generation

  • Prospective observational study
  • Patient / clinician survey
  • Preference study
  • Qualitative study
  • Structured expert elicitation

Secondary Data Analysis

  • Primary / secondary EMR
  • Insurance claims database
  • Registry data
  • External control arm
  • Medical chart review

Evidence Synthesis

  • Feasibility assessments
  • Meta-analysis
  • Indirect treatment comparison
  • Network meta-analysis
  • Population-adjusted analyses
  • Patient-level data meta-analyses

Projects are delivered by our specialised team of statisticians

RWE Perspectives

For more information on our Real-World Evidence services or to request a quote, please contact Declan Summers

Get In Touch

Contact Declan Summers
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